Category Archives for Japanese Health

Popping Pills in Japan – 2nd Largest Pharma Market

Japan loves to pill popJAPAN – 2nd Largest Pharma Market

By Nitesh Bhele

Japan is the 2nd largest Pharmaceutical & biotechnology market in the world after the United States. Japan accounts for around 10 percent of the global pharma market, compared with 39 percent for the U.S. and 21 percent for Western Europe approximately. The pharmaceutical market has size around $ 150 billion, where biotechnology market value of Japan is projected to sharply increase reaching $100 billion by 2020. The Japan government recognized the big demand on this sector and realized the need of having a national strategy for Pharmaceutical & biotechnology development. Number of plans based on the Biotechnology Strategy Guidelines have been implemented since last few years.

Currently, Japan still lags behind the U.S. in this sector but it is taking a lead in the field of gene analysis, genetic recombination, bioinformatics and others. With the great effort of the government by providing substantial resources to this sector, biotechnology is expected to become a major sector. Furthermore, The Industrial Cluster Plan Policy is one of the efforts of the government to strengthen the capabilities of the defined regional cluster areas to develop new technologies and product. Among the 17 projects, 8 of them are focused on the biotechnology industries. Moreover, Japan has a much lower penetration of generics compared to most of the major markets which is advantageous for the big pharma.

In Japan, every citizen has to participate in the insurance program managed by Government of Japan National Health Insurance (NHI).  National Health Insurance (NHI) scheme as well as the majority of health care spending is publically funded. The government is taking number of initiatives to control spending, such as encouraging use of cheaper generic drugs, self-management of chronic diseases, and preventive care. A biennial NHI pricing review usually results in price reductions. This also is one of the most significant challenges faced by pharmaceutical companies in the Japanese market is the practice of biennial price cuts. Overall, the average cut of 5.64% will be applied on a drug price basis in the 2014 price revisions similar to the price cut of 6% applied in the 2012 price revisions. Market expansion based re-pricing rules as well as the special additional price cut being implemented this year on products for which the first generic was approved five years ago and have less than 20% generic replacement rate by volume will hamper the growth of the domestic pharmaceutical industry In addition, a new health technology assessment (HTA), expected to be implemented in 2016, could make it more difficult for life sciences companies to obtain competitive launch pricing and market access unless the new treatment is deemed innovative and cost-effective. Also, while the use of cost-saving generic drugs has been proportionally lower in Japan than in other developed markets, the government has strengthened the incentives for healthcare providers to prescribe generics. The new drug development premium awarded to innovative products shields the products from biennial National Health Insurance (NHI) price reductions during their patent protection period. This premium will enable patented branded products in its market expansion. During the 2014 NHI price revisions, 397 active ingredients (758 products) have been granted the exemption, over and above the 367 active ingredients considered for the treatment in the 2012 revision.

(All statements made in this video/article does not reflect our personal interest or belief about pharmaceuticals here at Nihon Scope)

Takeda Pharmaceutical, Japan’s largest pharmaceutical company and Asia and a top 15 pharmaceutical company. The company has over 30,000 employees worldwide, looks likely to increase its global footprint merger & acquisition done by it all over world. Otsuka’s $3.5bn acquisition of California-based neurologic disease specialist Avanir Pharmaceuticals in December 2014 is an even more potent demonstration of Japanese companies’ greater focus on global M&A.

Indeed, generic manufacturers from around the world – but especially generic specialists such as India – are looking to Japan as a source of future expansion. According to the Economic Times, Indian generics giants including Dr Reddy’s, Lupin, Sun Pharma and Glenmark are exploring options for tapping into the growing Japanese generics market.

Active pharmaceutical ingredient (API) and generic finished dose suppliers who recognize this growth potential and understand the specific needs and challenges unique to the Japanese market stand to see significant earnings in this region over the coming years. The global Active Pharmaceutical Ingredient Market is expected to reach USD 205.51 billion by 2020 from USD 150 billion in 2015, at a CAGR of 6.5% during the forecast period .The active pharmaceutical ingredient (API) market in Asia is growing at an increasingly rapid pace. From 2007 to 2011, it went from 24.5 to 28.5 percent of the world market. From now through 2017, it should expand at a rate of 8.2 percent annually. This puts Asia’s API market worth $33 billion currently at more than $50 billion by 2017.

Japan has long led the rest of Asia in demand for APIs. In 2012, the market for APIs in Japan was the largest in Asia, at $15.5 billion. Many foreign API firms from India, Europe and the US are actively selling their APIs on the Japanese market. Japan’s share of innovator APIs is high, and demand is growing especially in the biotech drug sector. But API generics are also starting to gain ground in Japan. Chinese and Indian firms have recently flooded Japan’s market with inexpensive APIs. The accompanying price competition has forced some Japanese API manufacturers out of their own domestic market. An increasing number of foreign pharmaceutical companies are selling APIs on the Japanese market. Sometimes they sell to domestic drug manufacturers and sometimes they sell to foreign drug companies manufacturing products in Japan.

In April 2013, India’s Dishman Pharmaceuticals and Chemicals announced the company was on track to post an almost fivefold growth in revenue for APIs sold in Japan through the end of 2013. Revenue from Japanese sales reached $2 million in 2012, and 2013 revenue is expected to increase to $10 million. The company currently supplies APIs to more than 10 Japanese companies. In February 2012, Pfizer Japan launched two new APIs in Japan. One was part of the diabetes treatment glimepiride (Amaryl), while another was part of the antiarrhythmic agent pilsicainide (Sunrythum). Aside from these two APIs, Pfizer Japan launched another 16 APIs in Japan in 2012. If foreign API manufacturers pay attention to the Japanese API market, they will find excellent sales opportunities, especially in the innovative and generic API segments. Key market players Teva Pharmaceuticals limited (Israel), Sun Pharmaceuticals Industries Limited (India), Dr. Reddy’s Laboratories Ltd. (India), Aurobindo (India), Novartis International AG (Switzerland), Boehringer Ingelheim (Germany), Albemarle Corporation (U.S.), Sigma Aldrich (U.S.), Mylan (U.K.), Allergan plc. (Ireland). Stakeholders include Manufacturers of API Distributors and Suppliers of APIs, Potential Investors in the API Market, Pharmaceutical Companies, Biotechnology Companies, Contract Manufacturing Organizations and Healthcare Payers

According to Catenion’s , pharmaceutical industry of Japan faces two fundamental problems for which it has not yet found an answer; these problems are firstly, an inadequate approach to managing innovation and secondly, a profound misunderstanding of the nature of risk and consequently poor risk management. The industry’s poor innovation track record is shown by the statistics of drug approvals by the FDA. There has been a long-term trend of a decrease in the number of NCEs and NBEs despite rapidly increasing R&D budgets. A recent study by Czerepak and Ryser published in Nature Drug Discovery shows that for the period between January 2006 and December 2007, barely 35% of the drugs approved by the FDA originated in the pharmaceutical industry. Less than half of these qualified for the label “novel drug and new chemical structure”.

Industry critics have used statistics such as these to argue that Big Pharma is shying away from true innovation and pursuing mostly me-too projects. A quick look at company pipelines shows this to be a wrong conclusion. There is an abundance of exciting, highly innovative projects and risky science going on at most companies. While some industry observers and investors continue to hope there might be an innovation backlog in the wake of unprecedented progress in molecular biology, disease understanding, lab technologies and novel drug formats, others are more pessimistic.

Turning to the second issue, Catenion have identified, the pharmaceutical business is a risky business par excellence but the nature of risk is often not fully appreciated by operators. Of course pharmaceutical executives know the scientific, technical, regulatory and commercial risks of their business. They spend a lot of their time devising and executing risk mitigation activities for these risks at the operational level. The argument we wish to make here is that there is too little awareness that risk must be managed properly at the strategic level as well. Such strategic risk management requires more sophisticated methods than those generally used in the industry today. There are three major points to our argument, covering the nature of risk itself, correlated risk in the R&D pipeline and the degree of risk diversification at the corporate level.

(All statements made in this video/article does not reflect our personal interest or belief about pharmaceuticals here at Nihon Scope)

Lupin is the only Indian pharma company to have a presence in the Japanese generic market from which it currently earns about 12% of annual revenue. Till date, Lupin Ltd has made two buyouts in Japan: Tokyo-based I’rom Pharmaceutical Co. Ltd in 2011 and Kyowa Pharmaceutical Industry Co. Ltd in 2007. Sun Pharma, which acquired Ranbaxy Ltd for $4 billion last year, also plans to raise up to Rs.12,000 crore through convertible debentures or a qualified institutional placement (QIP) for expansion and acquisitions. Japan, where drug sales were estimated at $115 billion in 2013, accounts for nearly 10% of the global pharma market according to a 2014 Deloitte report. The growth will mainly come from higher generic penetration. The government is keen to have a larger generic share to reduce their healthcare costs. An ageing population and mounting health costs have prompted the Japanese government to try and increase the presence of generic drug makers, bringing the Japanese market under the radar of Indian pharmaceutical companies.

According to Deloitte report, Japan’s rapidly ageing population just over a quarter of the population was aged 65+ in 2013, up from 12% in 1990, and accounting for over 50% of the country’s healthcare costs is expected to drive demand for pharmaceuticals in 2014-2018.The state-funded National Health Insurance scheme covers every citizen in Japan. In 2010, as part of efforts to increase the generic penetration, the government launched a series of reforms targeting 30% of the drug market by 2014 and 60% by 2017, from 18% in 2010.

Besides the reported move by Sun Pharma, other Indian generics makers, including Dr Reddy’s Laboratories and Glenmark Pharmaceuticals Ltd, are exploring options for entering Japanese generics market with their formulation drugs.

By Nitesh Bhele, Pharmaceutical & Healthcare Marketer

Full article here – Page No 60…/…/ISAApr01152016/index.html

Japanese Laundry Detergent + Organic/Natural Brands

Japanese Laundry Detergent and SafenessPopular Laundry Detergent in Japan + Natural/Organic Brands

I’m someone who knows more then the general public does when it comes to the chemical warfare that we are exposed to every day, I’ve done the research and have seen the physical effects of bad detergents, not only are most horribly bad for the environment, they are also horribly bad for YOU, and especially children.

It's possible to learn Japanese while watching your favorite anime

Most laundry detergent are so bad for you, that the lobbyist here in America made it so that laundry detergent manufactures do not BY LAW have to tell you what it’s in the mixture of death. To be blunt, it’s a toxic concoction of petroleum based products and many are straight responsible for the rise in asthma and respiratory challenges as well as cancer. To push this even further in many main stream brands of detergents have a chemical used in them that are actually used in laboratory conditions to INDUCE asthma attacks for research!

So here is a basic run down of popular detergents in Japan, and few you may want to lean towards when given the option! Overall it’s not super popular for natural/organic safe detergents in Japan, but they do exist! When my wife and I get over there we’ll update with a new post when we find more options for those that care about their health.


Words to know when reading ingredients and words on detergent boxes/bottles:

洗濯 せんたく sentaku laundry
洗剤 せんざい senzai detergent
粉末 ふんまつ funmatsu powder
液体 えきたい ekitai liquid
固形 こけい kokei solid
石鹸, 石けん, せっけん せっけん sekken soap
柔軟剤 じゅうなんざい juunanzai fabric softener
柔軟仕上げ剤 じゅうなんしあげざい Jūnan shiage-zai fabric softener
詰替用 or つめかえ用 つめかえよう tsumekaeyou refill
液性 えきせい ekisei pH
香り かおり kaori scented
入り いり Iri Included
なし Nashi without
おしゃれ着 おしゃれちゃく Oshare chaku fashionable clothes
無添加 むてんか mutenka – no additives
エコ洗剤えこせんざいEkosenzai – Eco-detergent
環境洗剤 かんきょうせんざい kankyousenzai – Environmental detergent


成分 せいぶん seibun ingredients
界面活性剤 かいめんかっせいざい kaimenkasseizai surfactant
合成 ごうせい gousei synthetic
純石けん じゅんせっけん junn sekken pure soap
酸素系 さんそけい sansokei color-safe bleach
塩素系 えんそけい ensokei chlorine bleach
衣料用漂白剤 いりょうようひょうはくざい iryouyou hyouhakuzai hyouhakuzai Clothing bleach
漂白剤 ひょうはくざい hyouhakuzai bleaching agent
漂白剤なし ひょうはくざいなし Hyōhaku-zai nashi no bleach
蛍光増白剤 けいこうぞうはくざい keikouzouhakuzai optical brighteners
酵素 こうそ kouso enzymes
アルカリ剤 アルカリざい arukarizai alkaline agents
水軟化剤 みずなんかざい mizunankazai water softener
柔軟剤入り じゅうなんざいいり juunanzai-iri including fabric softener
無香科 むこうか Mukou ka No added fragrances
配合していません はいごうしていません Haigō shite imasen Not formulated

Laundry detergent is typically labeled as: 洗濯用合成洗剤 on the back following 品名 (hinmei), which means “product name”

Common Brands:

Fabric softener bottles look very similar to laundry detergent bottles, but instead, their 品名 (“product name”) on the table on the back of the bottle will be 柔軟仕上げ剤. Also, fabric softeners tend to be extremely scented, which is reflected by the flowers, berries and other representations of scents on the bottle. Fabric softener has been shown to be the most poisonous part of doing laundry. The EPA actually says on their own website that if some of these chemicals are floating around in the air that they are to be taken serious and to be avoided. DO NOT USE FABRIC SOFTENER. It’s better to get dryer balls instead to make your clothes less starchy.


Safe Reusable Drier Balls* DRY FASTER AND UNIQUE DRYER BALLS – These dryer balls comes in a set of 4 with 2.7″ x 2.7″ laundry ball size. The unique design separate clothes to provide more airflow and accelerates the drying process up to 40 percent and serve as all natural fabric as well, so you can save more time, energy and money.

  • MAGICALLY SOFTEN FABRIC – Our durable dryer balls laundry brilliantly make fabric fluffier, softer and wrinkle-free. It also eliminates toxins while retaining the smell of essential oils to make the clothes smell great. If you feel just a hint of static, feel free to return this product within 30 days.

  • SUPER EASY TO USE AND REUSABLE – The ball is big enough and very easy to use, simply place the magic drying balls for laundry into dryer appliance with the laundry load. It’s also durable and reusable with 1000 times life circle so you don’t need to use fabric softener or any static products anymore. It’s a money-saver!

  • PREMIUM ECO-FRIENDLY MATERIAL – The spike ball is made of superb eco-friendly Hypoallergenic PVC Which is non-toxic and safe to use for all fabrics. It will be extremely safe for people with an allergy or people with sensitive skin that can’t use fabric softener.

They’re super affordable and my wife and I used ours the entire time while in Japan which was about 2 years. We left them with a friend and she is still using them. We’ll be purchasing another set when we leave and leave the ones we purchased when we returned with some family. It’s sort of a no brainer, it works and it’s reuseable and you’re literally not killing yourself and your family to be blunt about it.

Click here to learn more



Chemical Crap Downy Detergentさらさ (Sarasa)

Pink Brand of detergent in Japanレノア (Lenor)

Renoa Japanese Brandファーファ (Fafa)

Weird Bear Launry Detergent Ripoffソフラン (Soflan)

Soflan Laundry Detergent in JapanMieux Luxgeous

Fancy Cleaning AgentsAroma Rich
Interesting smelling detergents in Japanハミング (Humming)

An odd cleaning detergent called humming


Popular brands:

ブライト (Bright)
Bright Cleanersハイター (Haiter)

A popular cleaning product in Japanワイドハイター (Wide Haiter)

Widde Haiter Brand

マイブリーチ (My Bleach)

My Bleach Japanese Brand

Organic Detergent in JapanDetergent for super fine clothes: (Good to Buy)

The Laundry Detergent has premium ingredients and can save you a trip to the dry cleaners for certain fancier clothing. It also has a premium price at $42.73 for 500ml

Aroma materials / ingredients detergent components (surface Activator equivalent amount): high grade alcohol-based (non-ionic) 9%, coconut oil fatty acid alkanolamide (ME A use) 7%, other: ro purified ingredients: Lavender essential oil 1% 83% (additive is any unused) water / liquid: neutral / applications: cotton, hemp, chemical fiber, wool, silk fabric washing


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